Imagine that you’re sitting on your couch relaxing, watching television when, all of a sudden, you feel a sharp, piercing pain in your chest and your left arm goes numb or tingles. You begin to feel nauseous and lightheaded and you can’t seem to catch your breath. These are all symptoms of a heart attack, a deadly disease that can occur at any time without any prior warning or symptoms. In fact, a recent government survey reveals that over 60% of heart attack deaths were unexpected or sudden.
As you can see, heart disease is a serious condition – the number one killer of men and women in the United States. More than 60 million Americans are living with some form of heart disease right now and approximately one million of them will die of the condition this year. The toll that cardiovascular disease takes in both emotional and financial terms is staggering; in 2002, caring for heart disease patients is expected to cost the nation almost $330 billion. Rates of cardiovascular disease and its cost are only expected to skyrocket even higher as the population ages.
While these statistics are grim, there is a great deal you can do to prevent and control cardiovascular diseases. In this special report, I will review how, through exercise, diet and taking the correct nutritional supplements, you can keep your cardiovascular system operating in peak condition for 100 years or longer. Take action now to ensure a healthy heart far into the future!
Understanding How Your Heart Works
- Sodium and high blood pressure. The scientific evidence establishes that diets high in sodium are associated with a high prevalence of hypertension or high blood pressure and with increases in blood pressure with age, and that diets low in sodium are associated with a low prevalence of hypertension or high blood pressure and with a low or no increase of blood pressure with age.
- Omega-3 fatty acids and coronary heart disease. This qualified claim states that diets high in omega-3 fatty acids, commonly found in fish, may decrease the risk of developing heart disease.
- Folic acid and homocysteine. Increased intake of folic acid has been shown to reduce levels of homocysteine, a substance that has been linked with a greater risk for cardiovascular disease.
Natural Heart Helpers
Besides the recommended nutrition and lifestyle changes, researchers have identified a number of dietary supplements that can help to prevent heart disease and even reverse debilitating conditions such as atherosclerosis. These all-natural solutions are gentler on your heart than many harsh pharmaceutical drugs. Anyone concerned about their cardiovascular health should consider adding these heart-smart supplements to their daily regimen.
B Kind To Your Heart
The B vitamins, but especially vitamin B6, vitamin B12 and folic acid, are especially important for fighting high homocysteine levels. Homocysteine has moved to center stage as a major independent risk factor for heart disease, on par with smoking and high cholesterol. It is a sulfur-containing amino acid that is normally produced in the body in small amounts from the amino acid methionine. Its normal role is to control growth and support bone and tissue formation. However, researchers believe high levels of the substance may damage the inner artery lining, contribute to atherosclerosis and promote blood clot formation. Elevations in homocysteine levels are found in about 20 to 40 percent of patients with heart disease.
Homocysteine levels in the blood begin to rise due to a deficiency of the three B vitamins listed above. Other factors also play a role including aging, menopause, heredity and cigarette smoking.
Conversion of homocysteine into a useful amino acid is the only reaction in the human body that requires both folic acid and vitamin B12. Without adequate amounts of these two vitamins, homocysteine cannot be converted and soon builds up in the blood. Although homocysteine poses as much cardiac risk as cholesterol, the good news is that homocysteine levels react much more swiftly to dietary treatment.
Vitamin B6, along with folic acid, was recently found to lower homocysteine levels in people with diseased arteries. The two-year study followed 78 siblings who were given 5 mg of folic acid and 250 mg of vitamin B6 daily. A control group of 80 patients received an inactive placebo. At the end of the study period, the authors found the siblings who received vitamins were less likely to have irregular readings on an electrocardiogram taken after exercise – an indirect measure of the health of coronary arteries.
New Irish research has found that the role of vitamin B12 in the reduction of blood homocysteine levels may be more important than previously believed. While the vitamin must be present for folate to exert its homocysteine-lowering effects, B12’s role has always been considered to be far less important. Now, however, researchers have found that supplementing with both folic acid and vitamin B12 “is likely to be much more effective in lowering homocysteine concentrations, with potential benefits for reduction of the risk of cardiovascular disease.”
Folic acid’s role in lowering homocysteine has been well-researched, but new evidence reveals that the vitamin may benefit the heart in other ways, too. One study has shown that supplementing with 5 mg of folic acid helped to improve the function of the endothelium (the lining of the arteries) independently of lowering homocysteine levels. Another study found that people who consumed at least 300 micrograms (mcg) of folate per day had a 20% lower risk of stroke and a 13% lower risk of cardiovascular disease than their peers who consumed less than 136 mcg of folate per day. The findings accounted for other heart disease risk factors such as cholesterol, blood pressure, smoking and obesity.
Policosanol: Nature’s Own Cholesterol-Buster
Coenzyme Q10 (CoQ10), also known as ubiquinone, is a powerful antioxidant discovered by researchers at the University of Wisconsin in 1957. Shortly thereafter CoQ10’s other life-sustaining functions were revealed. The name of this supplement comes from the word ubiquitous, which means “found everywhere.” That’s because CoQ10 is found in every cell in the body. It plays a fundamental role in the mitochondria, the parts of the cell that produce energy from food.
Japanese scientists first discovered the therapeutic properties of CoQ10 in the 1960s. Today, it is widely prescribed for heart conditions in Europe and Israel as well as Japan. CoQ10 appears to assist the heart during times of stress on the heart muscle, perhaps by helping it use energy more efficiently. CoQ10 is most often used to treat cardiovascular diseases such as congestive heart failure, high blood pressure and angina. It is also prescribed for diabetes, periodontal disease, immune deficiency, cancer, as a weight-loss aid, muscular dystrophy and as a performance-enhancing agent in athletes.
An important yet frequently overlooked component in the overall treatment of cardiovascular disease is the promotion of a better functioning heart. Very good evidence tells us that CoQ10 can help people with congestive heart failure. In this serious condition, the heart muscles become weakened, resulting in poor circulation and shortness of breath. Research shows that people with congestive heart failure have significantly lower levels of CoQ10 than healthy people. This fact alone doesn’t prove that CoQ10 supplements will help congestive heart failure. However, it prompted medical researchers to try using CoQ10 as a treatment for heart failure. Results have been positive. At least nine double-blind studies have found that CoQ10 supplements can markedly improve symptoms and objective measurements of heart function when they are taken along with conventional medication.
Cardiomyopathy is the general name given to conditions in which the heart muscle gradually becomes diseased. Several small studies suggest that CoQ10 supplements are helpful for some forms of cardiomyopathy. In addition, an open study of 109 people with high blood pressure found significant improvements in systolic and diastolic blood pressure during treatment with an average dosage of 225 mg daily of CoQ10. In fact, over four months, 51 percent of treated individuals were able to stop taking one to three blood pressure medications. These marked benefits persisted for the full length of the study (one year). Similar benefits have been seen in other open studies.
Every cell in the body needs CoQ10 but no U.S. Recommended Dietary Allowance has been established for this important substance because the body can manufacture CoQ10 from scratch. However, numerous drugs impair the body’s ability to synthesize CoQ10 including oral diabetes drugs, tricyclic antidepressants, phenothiazines, beta-blockers and cholesterol-reducing medications in the statin family. CoQ10 levels also decline during the aging process. Therefore, topping off your natural production can have many life-enhancing benefits.
Because CoQ10 is found in all animal and plant cells, we obtain small amounts of this nutrient from our diet. However, it is very difficult to get a therapeutic dosage from food. The typical recommended dosage of CoQ10 is 30 to 300 mg a day, often divided into two or more doses. CoQ10 is fat-soluble and is better absorbed when taken in an oil-based soft gel form rather than in a dry form such as tablets and capsules.
Magnesium is a mineral needed by every cell of your body. About half of your body's magnesium stores are found inside cells of body tissues and organs, and half are combined with calcium and phosphorus in bone. Only 1 percent of the magnesium in your body is found in blood. Your body works very hard to keep blood levels of magnesium constant.
Magnesium is needed for more than 300 biochemical reactions in the body. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, and bones strong. It is also involved in energy metabolism and protein synthesis.
Evidence suggests that magnesium may play an important role in regulating blood pressure. Diets that provide plenty of fruits and vegetables, which are good sources of potassium and magnesium, are consistently associated with lower blood pressure. The DASH study (Dietary Approaches to Stop Hypertension) suggested that high blood pressure could be significantly lowered by a diet high in magnesium, potassium, and calcium, and low in sodium and fat. In another study, the effect of various nutritional factors on incidence of high blood pressure was examined in over 30,000 U.S. male health professionals. After four years of follow-up, it was found that a greater magnesium intake was significantly associated with a lower risk of hypertension. The evidence is strong enough that the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure recommends maintaining an adequate magnesium intake as a positive lifestyle modification for preventing and managing high blood pressure.
Other studies suggest that magnesium may play a broader role in cardiovascular health. Besides lowering blood pressure levels, magnesium has also been shown to thin the blood, making it less likely to clot and cause heart attacks and strokes; it also helps to relax blood vessels. Finally, magnesium supplementation may offer life-enhancing benefits to people already afflicted with congestive heart failure, a condition in which the heart is not functioning as well as it should due to high blood pressure or clogged arteries. A 1990 study found that patients who had normal levels of blood magnesium had a greater prognosis for survival than their peer who had low levels of the mineral. Only 45% of patients with low magnesium were expected to live a year, as compared to more than 70% of people who had adequate magnesium levels.
Plant Sterols: Slash Cholesterol Levels Naturally
Sterols are fatty substances found naturally in plants, seeds and nuts. There are three main types of sterols – beta-sitosterol, campesterol and stigmasterol. Sterols have a chemical makeup that is almost identical to that of cholesterol.
Numerous studies have shown that sterols may be effective in controlling cholesterol levels by blocking its absorption and preventing the liver from manufacturing it. Two recent studies have revealed that foods enriched with sterols can help to reduce elevated cholesterol levels by as much as 13 percent. In the first study, performed in Helsinki, Finland, researchers gave study participants with total cholesterol readings between 232 and 310 bread, meat and jam enhanced with plant sterols. After 15 weeks of eating the sterol-enriched foods, study participants were found to have greatly reduced total and LDL cholesterol levels.
In a study performed this year at the University of Munich in Germany, 63 healthy volunteers with moderately elevated LDL cholesterol levels were asked to use a margarine product containing 20 grams of phtyosterols for three weeks. Participants were then “crossed-over” to receive a margarine product that contained no sterols for an additional three weeks. Researchers found that after three weeks on the sterol-fortified margarine, subjects had drastically reduced total and LDL cholesterol levels and had improved HDL readings. Surprisingly, researchers found that sterols seemed to have the most benefits for subjects who ate a diet high in fat, especially saturated fat, and calories. This group was able to slash LDL levels by more than 11%!
Polyphenols: Drink Up for a Healthy Heart
Polyphenols, substances found in abundance in grape skin and present in red wine, may help to decrease production of a protein that causes blood vessels to constrict, reducing the flow of oxygen to the heart. The protein, endothelin-1, is believed to play a key role in the development of heart disease, according to researchers at Queen Mary University in London. Their findings support results of earlier studies showing that a moderate intake of red wine may lower the risk of heart disease. But while these earlier studies focused on the antioxidant properties of polyphenols – that is their ability to neutralize disease-causing free radicals in the body – results of this study suggest a new mechanism by which red wine might bring benefits.
According to the study, red wine polyphenols inhibit a group of enzymes that play a key role in cell regulation. Compounds that inhibit these enzymes have been shown to suppress endothelin production.
Green tea, another good source of polyphenols, may also help keep your cardiovascular system healthy. Green tea has been shown to prevent the oxidation of LDL cholesterol, a leading cause of artery damage. Japanese researchers found that after ingesting 300 mg of green tea polyphenol extract twice a day, participants had a significant lag time of 13.7 minutes before LDL cholesterol was oxidized. The researchers speculated that drinking green tea or supplementing with green tea extract might also inhibit the absorption of cholesterol and lower blood pressure.
One of the most important steps you can take to build a healthy heart is to limit the formation of free radicals. Free radicals are unstable compounds that the body produces during necessary metabolic functions such as breathing and burning food for energy; they may also come from environmental factors such as chemicals or cigarette smoke. Because free radicals are unstable they may react with and damage certain molecules in the body, interfering with their ability to function normally. This damage is known as oxidation. Free radical oxidation has been linked to about sixty different diseases, including heart disease.
Fortunately, it’s not difficult to limit free radical damage. Nutrients known as antioxidants are powerful defenders against free radical oxidation. A number of antioxidants have been shown in clinical trials to be especially helpful for heart health. They include:
· Grapeseed extract: A rich source of one of the most beneficial groups of plant flavonoids – proanthocyanidins (PCOs). PCOs are potent antioxidants and free radical scavengers. Grapeseed extract also helps to limit the production of certain enzymes that damage blood vessels. In addition, animal studies have shown that PCOs have a number of cardio-protective effects including lowering cholesterol levels and reversing the progress of atherosclerosis (hardening of the arteries).
· Lycopene: Rich, red tomatoes that are eaten raw in salads and cooked in tomato sauce are packed with a powerful antioxidant called lycopene. Recent studies show that patients who have high levels of lycopene in their blood plasma have a lower incidence of atherosclerosis. Atherosclerosis risk gradually decreases as lycopene levels increase.
· Selenium: This mineral is a component of one of the body’s major antioxidants, glutathione peroxidase. As such, selenium plays an important role in protecting the body from the free radical oxidation that can lead to cardiovascular disease. Studies have shown that rates for heart disease are highest where selenium levels are lowest.
· Vitamin C: Clinical studies have shown that vitamin C provides numerous benefits to the cardiovascular system. This multi-tasking vitamin may lower blood pressure and cholesterol levels as well as strengthen artery walls. Now, British researchers have also found that people with the highest vitamin C intakes had the lowest death rates from heart disease.
· Vitamin E: Of all the antioxidants, vitamin E is the best documented for the prevention of heart disease. Vitamin E is especially important to inhibit the oxidation of LDL cholesterol – a leading cause of heart disease. A recent Italian study found that elderly people who had high levels of vitamin E in their blood were ten times less likely to die from cardiovascular disease than their peers with low levels of the vitamin. In fact, an inadequate supply of vitamin E in the bloodstream may be the single most important factor in the development of heart disease – even more relevant than high cholesterol or blood pressure.
· Hawthorne: In Europe, hawthorn is widely regarded as a safe and effective treatment for the early stages of congestive heart failure. Significant, solid research surrounds the herb as a treatment for congestive heart failure. Between 1981 and 1994, thirteen controlled clinical studies of hawthorn were performed, most of them double blind. In all, 808 people participated in these trials. Cumulative results strongly suggest that hawthorn is an effective treatment for this condition. Comparative studies suggest that hawthorn is about as effective as a low dose of the conventional drug captopril.
References
Albert CM et al. “Blood levels of long-chain n-3 fatty acids and the risk of sudden death.” N Engl J Med 2002; 346(15): 1113-1118.
Appel LJ. “Nonpharmacologic therapies that reduce blood presure: A fresh perspective.” Clin Cardiol 1999; 22: 1111-1115.
Appel LJ et al.” A clinical trial of the effects of dietary patterns on blood pressure.” N Engl J Med 1997; 336: 1117-1124.
Ascherio A et al. “A prospective study of nutritional factors and hypertension among US men.” Circulation 1992; 86: 1475-1484.
Burke BE et al. “Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension.” South Med J 2001; 94(11): 1112-1117.
Castaño G et al. “Effects of policosanol in older patients with type II hypercholesterolemia and high coronary risk.” Journal of Gerontology 2001; 56A(3): M186-M192.
Castaño G et al. “A long-term study of policosanol in the treatment of intermittent claudication.” Angiology 2001; 52(2): 115-125.
Doshi SN et al. “Folic acid improved endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.” Circulation 2002; 105(1): 22-26.
Madsen T et al. "C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease." American Journal of Cardiology 2001; 88:1139-1142.
Reusser ME and McCarron DA. “Micronutrient effects on blood pressure regulation.” Nutr Rev 1994; 52: 367-375.
Sacks FM et al. “Rationale and design of the Dietary Approaches to Stop Hypertension trial (DASH). A multicenter controlled-feeding study of dietary patterns to lower blood pressure.” Ann Epidemiol 1995; 5: 108-118.
Sacks FM et al. “A dietary approach to prevent hypertension: A review of the Dietary Approaches to Stop Hypertension (DASH) Study.” Clin Cardiol 1999; 22: 6-10.
Simopoulos AP. “The nutritional aspects of hypertension.” Compr Ther 1999; 25: 95-100.
Svetkey LP et al. “Effects of dietary patterns on blood pressure: Subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial.” Arch Intern Med 1999; 159: 285-293.